Therefore, our data suggest that identification of epithelial cells as single intact cells could be used as an additional diagnostic feature, with the caveat that it is somewhat operator-dependent.
In contrast, these characteristics are uncommon features of other types of gastric lesion. Gualtieri et al. Signet ring cells have also been described in other epithelial neoplasms, such as transitional cell carcinomas DeMay, ; Meuten, , although the there is a low likelihood that such tumours would metastasise to the stomach. The frequency of gastric adenocarcinoma in our case series was intentionally biased Therefore, predictive values need to be adjusted according to the actual prevalence of gastric adenocarcinoma in clinical practice. However, the LR values and the high DO ratio suggest that this test would be reliable, regardless of the true prevalence.
The DO value indicates that the odds for positivity among subjects with adenocarcinoma is times higher than the odds for positivity among subjects without adenocarcinoma Glas et al. Comparison of cytohistologic techniques in diagnosis of gastroesophageal malignancy. Acta Cytologica 52, Diagnostic value of cytologic examination of gastrointestinal tract tumors in dogs and cats: 83 cases Journal of the American Veterinary Medical Association , Use of ultrasound-guided fine-needle aspiration biopsy and automated core biopsy for the diagnosis of gastrointestinal disease in small animals.
Veterinary Radiology and Ultrasound 34, Squash-prep cytology in the diagnosis of canine and feline nervous system lesions: A study of 42 cases. Squash-preparation cytology from nasopharyngeal masses in the cat: Cytological results and histological correlations in 30 cases. Journal of Feline Medicine and Surgery 10, Gastric mucinous adenocarcinoma with cutaneous metastases in a dog: Diagnosis by fine-needle aspiration cytology.
Journal Small Animal Practice 46, The Art and Science of Cytopathology, 1st Edn. Clinical Epidemiology: The Essentials, 5th Edn. Gastric carcinoma in the dog: A clinicopathological study of 11 cases. Journal of Small Animal Practice 30, The diagnostic odds ratio: A single indicator of test performance.
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Journal of Clinical Epidemiology 56, Gastric neoplasia. Tumors of the alimentary tract. In: Meuten, J. Tumors of Domestic Animals, 4th Edn. Second series. Ultrasonography findings in canine gastric neoplasia in 13 patients. Veterinary Radiology and Ultrasound 37, Crush preparation of gastroesophageal biopsy specimens in the diagnosis of malignancy. Acta Cytologica 34, Ultrasonographic appearance of primary gastric neoplasia in 21 dogs.
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Journal of Small Animal Practice 40, The measurement of observer agreement for categorical data. Simplifying likelihood ratios. Journal of General Internal Medicine 17, Squash preparation: A reliable tool in the intraoperative diagnosis of central nervous system tumors. Journal of Cytology 27, Canine gastric neoplasia: Utility of ultrasonography in diagnosis. Journal of the American Animal Hospital Association 33, Rapid cytodiagnosis of endoscopic biopsy specimens in gastrooesophageal malignancy.
Tropical Gastroenterology 14, Squash preparation and frozen section in intraoperative diagnosis of central nervous tumors. Acta Cytologica 42, Fundamentals of Veterinary Clinical Pathology, 2nd Edn. Atypical mitoses: Morphology and classification. Veterinary Clinical Pathology 38, Canine non-hematopoietic gastric neoplasia. Epidemiologic and diagnostic characteristics in 38 dogs with post-surgical outcome of five cases.
Cancer of the gastrointestinal tract. In: Withrow, S. Alimentary neoplasia in geriatric dogs and cats. Morphological characteristics and distribution patterns of epithelial cells in the cytological diagnosis of gastric cancer. Journal of Clinical Pathology 35, A and B. Squash preparation of a gastric biopsy from a dog with gastric adenocarcinoma showing signet ring cell morphology. Loosely cohesive medium-sized to large epithelial cells with a large cytoplasmic vacuole that contains pink amorphous material and displaces the nucleus eccentrically.
Romanowsky stain. Original magnifications x A and 1,x B. Histopathological section of a gastric biopsy from a dog with adenocarcinoma. Signet ring cells are the large cells with clear cytoplasm that displaces the nucleus to the periphery of the cell. Haematoxylin and eosin. Original magnification x.
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Microvacuolation in epithelial cells in a squash preparation of a gastric biopsy from a dog with gastric adenocarcinoma. Loosely cohesive epithelial cells with scant blue cytoplasm frequently containing clear discrete vacuoles, mainly with perinuclear distribution.
Lymph node without fatty hilum
A small sheet of epithelial neoplastic cells with moderately abundant blue cytoplasm distended by both discrete and indistinct border vacuoles. Original magnification 1,x.
Cuboidal neoplastic cells have finely vacuolated cytoplasm and multiple prominent nuclei. A lymphoplasmacytic infiltration is evident.
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Introduction 2. Cytopreparatory Techniques 4. Nodular Goiter 7. Follicular Neoplasms 8. Papillary Carcinoma Poorly Differentiated Insular Carcinoma Anaplastic Carcinoma Medullary Carcinoma Thyroiditis Malignant Lymphoma